Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markers—indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive ability—are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.
- Cover
- Front Matter
- Executive Summary
- 1. Report of the Oversight Committee
- I. Biologic Markers in Male Reproductive and Gametic Genetic Toxicology
- 2. Introduction
- 3. Clinical Evaluation of Male Infertility
- 4. Biologic Markers of Testicular Function
- 5. Biologic Markers of Epididymal Structure and Function
- 6. Biologic Markers of Accessory Sex Organ Structure and Function
- 7. Biologic Markers of Human Male Reproductive Health and Physiologic Damage
- 8. Assessing Transmitted Mutations in Mice
- 9. Markers for Measuring Germinal Genetic Toxicity and Heritable Mutations in People
- 10. Conclusions and Recommendations
- II. Biologic Markers in Female Reproductive Toxicology
- 11. Introduction
- 12. Biologic Markers of Genetic Damage in Females
- 13. Biologic Markers of Reproductive Development and Aging
- 14. Biologic Markers of Nonconceptive Menstrual Cycles
- 15. Developing Assays of Biologic Markers for Epidemiologic Studies: Experience with a Marker of Pregnancy and Early Loss
- 16. Conclusions and Recommendations
- III. Biologic Markers of Toxicity during Pregnancy
- 17. Introduction
- 18. Molecular Biology: Developing DNA Markers of Genotoxic Effects
- 19. Reproductive Immunology: Biologic Markers of Compromised Pregnancies
- 20. Cell Biology: Identifying Biologic Markers Expressed during Early Pregnancy
- 21. Physiologic Assessment of Fetal Compromise
- 22. Biologic Markers of Exposure during Pregnancy: Pharmacokinetic Assessments
- 23. Conclusions and Recommendations
- IV. Biologic Markers in Neurodevelopmental Toxicology
- 24. Introduction
- 25. Developmental Neurobiology of the Central Nervous System
- 26. Morphologic, Neurochemical, and Behavioral Responses to Toxic Agents
- 27. Methodologic Issues of Extrapolation from Animal Studies to Human Toxicant Exposure
- 28. Lead as a Paradigm for the Study of Neurodevelopmental Toxicology
- 29. Conclusions and Recommendations
- Appendix: Assessing the Validity of Biologic Markers: Alpha-Fetoprotein
- References
- Biographies
- Index
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