The Hanford Nuclear Reservation, where about two-thirds of the nation's weapons plutonium was produced from 1944 to 1987, is the site of the largest and most complex nuclear cleanup challenge in the United States. Section 3125 of the National Defense Authorization Act for Fiscal Year 2021 calls for a Federally Funded Research and Development Center (FFRDC) to develop a framework of decisions to be made among the supplemental treatment technologies, waste forms, and disposal locations for low-activity waste in the Hanford tanks. In addition, Section 3125 calls for the National Academies of Sciences, Engineering, and Medicine to provide a concurrent, independent peer review of the ongoing FFRDC analysis. This review report, the first of three to address the Congressional mandate, focuses on the technical quality and completeness of the FFRDC's draft framework.