The National Research Council closes the landmark series Drinking Water and Health with Volume 9, published in two parts:
Part I: DNA Adducts provides an overview of DNA adducts and their effects on human health, explores the techniques currently in use for detecting them, offers an outlook on future toxicity testing, and lists specific recommendations for action.
Part II: Mixtures explores the issues surrounding multiple-chemical exposure from drinking water and reviews options for grouping compounds so their toxicity in mixtures can be reliably assessed. The book describes alternative approaches and considers the option of developing a modified "hazard index" for chemical compounds.
- Front Matter
- Part I: DNA Adducts
- Executive Summary
- 1 Biologic Significance of DNA Adducts and Protein Adducts
- 2 DNA-Adduct Technology
- 3 Conclusions and Recommendations
- Appendix A: Drinking Water Contaminant Candidates for Development of Baseline Data on Formation of DNA Adducts
- Glossary
- Biographical Sketches
- Part II: Mixtures
- Executive Summary
- 1 Introduction
- 2 Pharmacokinetics and the Risk Assessment of Drinking Water Contaminants
- 3 Risk Assessment of Mixtures of Systemic Toxicants in Drinking Water
- 4 Assessment of Exposure to Organophosphorus Conpounds, Carbamates, and Volatile Organic Chemicals
- 5 Acetylcholinesterase Inhibitors: Case Study of Mixtures of Contaminates with Similar Biologic Effects
- 6 Volatile Organic Compounds (VOCs): Risk Assessment of Mixtures of Potentially Carcinogenic Chemicals
- 7 Conclusions and Recommendations for Research
- Appendix A: An Approach for Risk Assessment of Volatile Organic Chemicals in Drinking Water That Uses Experimental Inhalation Data and a Physiologically Based Pharmacokinetic Model
- Appendix B: A Model Illustrating Synergism
- Appendix C: Models of Response: Dose Additivity and Response Additivity
- Biographical Sketches
- Part III: Cumulative Index
- Index
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