Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants

Volume 4

  • Editor: National Academies Press
  • ISBN: 9780309067959
  • eISBN Pdf: 9780309593854
  • eISBN Epub: 9780309183512
  • Lloc de publicació:  United States
  • Any de publicació digital: 2000
  • Mes: Març
  • Pàgines: 386
  • Idioma: Anglés

The National Aeronautics and Space Administration (NASA) is aware of the potential toxicological hazards to crew members that might be associated with prolonged spacecraft missions. Despite major engineering advances in controlling the atmosphere within spacecraft, some contamination of the air appears inevitable. NASA has measured numerous airborne contaminants during space missions. As the missions increase in duration and complexity, ensuring the health and well-being of astronauts traveling and working in this unique environment becomes increasingly difficult.

As part of its efforts to promote safe conditions aboard spacecraft, NASA requested the National Research Council (NRC) to develop guidelines for establishing spacecraft maximum allowable concentrations (SMACs) for contaminants, and to review SMACs for various spacecraft contaminants to determine whether NASA's recommended exposure limits are consistent with the guidelines recommended by the subcommittee. In response to this request, the NRC first developed criteria and methods for preparing SMACs for spacecraft contaminants, published in its 1992 report Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants. Since then, the NRC's Subcommittee on Spacecraft Maximum Allowable Concentrations has been reviewing NASA's documentation of chemical-specific SMACs. This report is the fourth volume in the series Spacecraft Maximum Allowable Concentrations for Space Station Contaminants. The first volume was published in 1994 and the second and third in 1996.

Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants: Volume 4 has been reviewed in draft form by individuals chosen for their technical expertise and diverse perspectives in accordance with procedures approved by the NRC's Report Review Committee for reviewing NRC and Institute of Medicine reports. The purpose of that Independent review was to provide candid and critical comments to assist the NRC in making the published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process.

  • Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants
  • Copyright
  • Preface
  • Contents
  • SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SELECTED AIRBORNE CONTAMINANTS: INTRODUCTION
    • SUMMARY OF REPORT ON GUIDELINES FOR DEVELOPING SMACS
    • REVIEW OF SMAC REPORTS
    • REFERENCES
  • Appendix A Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants: Executive...
    • GUIDELINES FOR DEVELOPING SPACECRAFT MAXIMUM ALLOWABLE CONCENTRATIONS FOR SPACE STATION CONTAMINANTS ...
    • ENVIRONMENTAL CONTROL AND LIFE-SUPPORT SYSTEM
    • MODIFICATION OF CONTAMINANT TOXICITY BY ENVIRONMENTAL FACTORS
    • SOURCES AND TYPES OF DATA FOR ESTABLISHMENT OF SMACS
      • Chemical-Physical Characteristics of Toxicants
      • In Vitro Toxicity Studies
      • Animal Toxicity Studies
      • Clinical and Epidemiological Observations
      • Pharmacokinetics and Metabolism
      • Biological Markers
    • RISK ASSESSMENT (DEVELOPMENT OF EXPOSURE CRITERIA)
    • ISSUES IN MAKING RECOMMENDATIONS FOR THE ESTABLISHMENT OF SMACS
  • Appendix B Reports on Spacecraft Maximum Allowable Concentrations for Selected Airborne Contaminants
    • B1 ACETONE
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • TOXICOKINETICS AND METABOLISM
        • Absorption
        • Distribution
        • Excretion
        • Metabolism
      • TOXICITY SUMMARY
        • Acute and Short-Term Exposures
          • General
          • Irritation
          • Immunological and Hematological Effects
          • CNS Toxicity
          • Ataxia and Narcosis
          • Pulmonary Function and Cardiotoxicity
        • Subchronic and Chronic Exposures
          • Carcinogenicity
        • Genotoxicity
        • Reproductive Effects in Humans
        • Reproductive and Developmental Toxicity in Animals
        • Interaction with Other Chemicals
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • Irritation
        • Explosion
        • CNS Effects
        • Reproductive Effects
        • Spaceflight Considerations
      • RECOMMENDATIONS
      • REFERENCES
    • B2 C3 TO C8 ALIPHATIC SATURATED ALDEHYDES
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • TOXICOKINETICS AND METABOLISM
        • Absorption
        • Distribution
        • Excretion
        • Metabolism
      • TOXICITY SUMMARY
        • Acute and Short-Term Exposures
        • Subchronic and Chronic Exposures
          • Carcinogenicity
        • Genotoxicity
        • Developmental Toxicity
        • Reproductive Toxicity
        • Interactions with Other Chemicals
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • Mucosal Irritation
        • Nasal-Cavity Injury
        • Potential Liver Injury
      • RECOMMENDATIONS
      • REFERENCES
    • B3 HYDROGEN CHLORIDE
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • TOXICOKINETICS AND METABOLISM
        • Absorption
        • Metabolism
      • TOXICITY SUMMARY
        • Acute or Short-Term Exposures
        • Irritation to the Respiratory System
          • Human Studies
          • Animal Studies
        • Morphological Injuries to the Respiratory System
          • In Vitro Studies
          • Human Data
          • Animal Data
          • Functional Injuries to the Respiratory System
          • Systemic Injuries outside the Respiratory system
          • Death
          • Effect on Exercise Ability
        • Subchronic and Chronic Exposures
          • Toxicity of HCl in the Respiratory Tract
          • Human Studies
          • Animal Studies
          • Systemic Toxicity of HCl
        • Lack of Carcinogenic Response
          • Human Studies
          • Animal Studies
        • Genotoxicity
        • Developmental Toxicity
        • Interaction with Other Chemicals
        • Summary
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • 1-h and 24-h ACs
        • 7-d, 30-d, and 180-d ACs
          • AC Based on Human Exposure Data
          • AC Based on Animal Data
          • AC Summary Table
      • REFERENCES
    • B4 ISOPRENE
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • TOXICOKINETICS AND METABOLISM
        • Absorption
        • Distribution
        • Metabolism
        • Excretion
        • Comparative Toxicokinetics
      • TOXICITY SUMMARY
        • Acute Exposures
        • Short-Term Exposures
        • Subchronic and Chronic Exposures
          • Epidemiological Data
          • Animal Data on Noncancer End Points
          • Carcinogenicity
        • Genotoxicity
        • Developmental Toxicity
        • Reproductive Toxicity
        • Interactions with Other Chemicals
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • Perspective Provided by Comparison to 1,3-Butadiene
        • Short-Term Limits (1-h or 24-h Exposure)
          • Acute Neurotoxicity
          • Mucosal Irritation
          • Lesions of the Forestomach
        • Long-Term Exposure Limits (7- to 180-d Exposures)
          • Mucosal Irritation
          • Neurotoxicity
          • Hematological Changes
          • Liver Effects and Tumors
          • Respiratory-System Injury
          • Forestomach Epithelial Hyperplasia
          • Testicular Injury
          • Endogenous Production of Isoprene
      • RECOMMENDATIONS
      • REFERENCES
    • B5 METHYLHYDRAZINE
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • TOXICOKINETICS
        • Absorption
        • Distribution
        • Metabolism
        • Excretion
      • TOXICITY SUMMARY
        • Acute and Short-Term Exposures
          • Noninhalation Exposures
          • Acute Inhalation Toxicity
        • Subchronic and Chronic Exposures
          • Carcinogenicity
        • Genotoxicity
        • Reproductive Toxicity
        • Developmental Toxicity
        • Interaction with Other Chemicals
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • Nasal Injury
        • Carcinogenesis
        • Effects on Red Blood Cells
      • REFERENCES
    • B6 PERFLUOROPROPANE AND OTHER ALIPHATIC PERFLUOROALKANES
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • TOXICOKINETICS AND METABOLISM
        • Toxicokinetics
        • Metabolism
      • TOXICITY SUMMARY
        • Acute Exposures
          • General Toxicity
          • Cardiac Effects
        • Short-Term and Subchronic Exposures
        • Genotoxicity
      • EXPOSURE LIMITS
        • Exposure Limits Set by Other Organizations
        • Nasa Spacecraft Maximum Allowable Concentrations (SMACs)
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS (ACS) FOR EXPOSURES
        • ACs Based on the CNS Effects of the Acute Exposure Studies
        • ACs Based on Cardiac Effects
        • ACs Based on Subchronic Animal Exposure Data
        • SMACs for Other Volatile Perfluoroalkanes
      • ACKNOWLEDGMENTS
      • REFERENCES
    • B7 POLYDIMETHYLCYCLOSILOXANES
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • TOXICOKINETICS AND METABOLISM
        • Absorption
        • Distribution
        • Elimination
        • Metabolism
      • TOXICITY SUMMARY
        • Acute and Short-Term Exposures
          • Hexamethylcyclotrisiloxane
          • Octamethylcyclotetrasiloxane
          • Decamethylcyclopentasiloxane
        • Subchronic and Chronic Exposures
          • Hexamethylcyclotrisiloxane
          • Octamethylcyclotetrasiloxane
          • Decamethylcyclopentasiloxane
        • Carcinogenicity
        • Genotoxicity
        • Reproductive Toxicology
        • Developmental Toxicity
        • Interactions with Other Chemicals
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • Possible Liver Injury
        • Hexamethylcyclotrisiloxane
        • Octamethylcyclotetrasiloxane
        • Decamethylcyclopentasiloxane
      • RECOMMENDATIONS
      • REFERENCES
    • B8 DICHLOROFLUOROMETHANE (FREON 21)
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • UPTAKE, METABOLISM, AND TOXICOKINETICS
      • TOXICITY SUMMARY
        • Acute and Short-Term Exposures
          • CNS Effects
          • Lethality
          • Respiratory and Bronchopulmonary Effects
          • Heart and Circulatory System Effects
        • Subchronic and Chronic Exposures
          • Respiratory Toxicity
          • Hepatotoxicity
          • Pancreatic Effects
          • Other Systemic Effects
          • Carcinogenicity
          • Lethality
        • Genotoxicity
        • Reproductive and Developmental Toxicity
        • Spaceflight Effects
        • Synergistic Effects
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • CNS Depression
        • Cardiovascular Effects
        • Hepatotoxicity
      • REFERENCES
    • B9 CHLORODIFLUOROMETHANE (FREON 22)
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • UPTAKE, METABOLISM, AND TOXICOKINETICS
        • Absorption
        • Distribution
        • Excretion
        • Metabolism
      • TOXICITY SUMMARY
        • Acute and Short-Term Exposures
          • Lethality
          • Cardiac Arrhythmia
          • CNS Effects
        • Subchronic and Chronic Exposures
          • Endurance and Oxygen Consumption
          • Decreased Weight Gain
          • Histopathological Effects
          • Effects on Reflexes
          • Carcinogenicity
        • Genotoxicity
        • Reproductive and Developmental Toxicity
        • Spaceflight Effects
        • Synergistic Effects
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • Cardiac Sensitization to Arrhythmias
        • CNS Depression
        • Pathology, Endurance, and Reflexes
        • Carcinogenicity
      • REFERENCES
    • B10 TRICHLOROFLUOROMETHANE (FREON 11)
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • UPTAKE, METABOLISM, AND EXCRETION
      • TOXICITY SUMMARY
        • Acute and Short-Term Exposures
          • Cardiac Effects
          • Respiratory Effects
          • CNS Effects
        • Subchronic and Chronic Exposures
          • Carcinogenicity
        • Genotoxicity
        • Reproductive and Developmental Toxicity
        • Spaceflight Effects
        • Interaction with Other Chemicals
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • Cardiac Sensitization to Arrhythmia
        • Respiratory Effects
        • CNS Effects
      • REFERENCES
    • B11 DICHLORODIFLUOROMETHANE (FREON 12)
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • UPTAKE, METABOLISM, AND TOXICOKINETICS
      • TOXICITY SUMMARY
        • Acute and Short-Term Exposures
          • Cardiac Arrhythmia
          • Respiratory Effects
          • CNS Effects
        • Subchronic and Chronic Exposures
          • Carcinogenicity
        • Genotoxicity
        • Reproductive and Developmental Toxicity
        • Spaceflight Effects
        • Synergistic Effects
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • Cardiac Sensitization to Arrhythmias
          • Respiratory Effects
      • REFERENCES
    • B12 4-METHYL-2-PENTANONE
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • TOXICOKINETICS AND METABOLISM
        • Absorption
        • Distribution
        • Metabolism
        • Excretion
      • TOXICITY SUMMARY
        • Acute and Short-Term Exposures
          • Mucosal Irritation
          • CNS Effects and Death
          • Renal Effects
          • Hepatic Effect
        • Subchronic and Chronic Exposures
          • Hypercholesterolemia
          • Renal Effects
          • Hepatic Effects
          • Carcinogenicity
        • Genotoxicity
        • Reproductive Toxicity
        • Developmental Toxicity
        • Interaction with Other Chemicals
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • Mucosal Irritation
        • CNS Depression
        • Establishment of SMAC Values
      • RECOMMENDATIONS
      • REFERENCES
    • B13 CHLOROFORM
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • TOXICOKINETICS AND METABOLISM
        • Absorption
        • Distribution
        • Excretion
        • Metabolism
      • TOXICITY SUMMARY
        • Acute and Short-Term Exposures
          • Cardiac Effects
          • CNS
          • Hepatotoxicity
          • Lethality
          • Nausea
          • Nephrotoxicity
          • Resistance to Respiratory Infection
        • Subchronic and Chronic Exposures
          • Carcinogenicity
          • CNS Effects
          • Hepatotoxicity and Pneumonitis
          • Lethality
          • Nasal Toxicity
          • Nausea and Vomiting
          • Nephrotoxicity
        • Genotoxicity
        • Reproductive Toxicity
        • Developmental and Fetal Toxicity
        • Interaction with Other Chemicals
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • Carcinogenicity
        • Cardiac Arrhythmia
        • CNS Depression
        • Hepatotoxicity
        • Nephrotoxicity
        • Reproductive and Developmental Toxicity
        • Spaceflight Effects
      • RECOMMENDATIONS
      • REFERENCES
    • B14 FURAN
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • TOXICOKINETICS AND METABOLISM
        • Absorption
        • Distribution
        • Elimination
        • Metabolism
      • TOXICITY SUMMARY
        • Acute and Short-Term Exposures
          • General Toxicity
          • Lethality
          • Nephrotoxicity and Hepatotoxicity
        • Subchronic and Chronic Exposures
          • Nephrotoxicity and Hepatotoxicity in Gavaged Rodents
          • Carcinogenicity
        • Genotoxicity
        • Reproductive Toxicity
        • Developmental Toxicity
        • Interactions with Other Chemicals
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • Ordinary Human Exposures
        • Acute Lethality and Hepatotoxicity
        • AC for a 24-h Exposure
        • Carcinogenicity
        • Estimation of a NOAEL for Cancer Risk in Gavaged Rats
        • Extrapolation from Rat NOAEL to Human Inhalation ACs
        • Is the Respiratory System a Target by Inhalation?
        • Spaceflight Effects
      • RECOMMENDATIONS
      • REFERENCES
    • B15 HYDROGEN CYANIDE
      • PHYSICAL AND CHEMICAL PROPERTIES
      • OCCURRENCE AND USE
      • TOXICOKINETICS, METABOLISM, AND MECHANISM OF TOXICITY
        • Toxicokinetics
        • Metabolism and Disposition
        • Mechanism of Toxicity
      • TOXICITY SUMMARY
        • Acute or Short-Term Exposures
          • Neurological Effects
          • Humans
          • Animals
          • Histopathological Lesions in the Brain
          • Humans
          • Animals
          • Cardiac Effects
          • Humans
          • Animals
          • Effects on the Respiratory System
          • Humans
          • Animals
          • Lethality
          • Humans
          • Animals
        • Subchronic and Chronic Exposures
          • Clinical Neurological Effects
          • Humans
          • Animals
        • Neurological Damage
          • Humans
          • Animals
          • General Toxicity and Pathology
          • Thyroid Effects
          • Humans
          • Animals
          • Reproductive and Developmental Toxicity in Animals
          • Carcinogenicity and Mutagenicity
        • Interactions with Other Chemicals
      • RATIONALE FOR ACCEPTABLE CONCENTRATIONS
        • ACs Set Based on CNS Effects in Humans
        • Testicular Effects in Rats
        • Thyroid Effects
      • RECOMMENDATIONS
      • REFERENCES