Scaling Up Treatment for the Global AIDS Pandemic

Scaling Up Treatment for the Global AIDS Pandemic

Challenges and Opportunities

  • Auteur: Pray, Leslie; Knobler, Stacey; Kelley, Patrick; Arya, Monisha; Debas, Haile; Curran, James
  • Éditeur: National Academies Press
  • ISBN: 9780309092647
  • eISBN Pdf: 9780309544511
  • eISBN Epub: 9780309165839
  • Lieu de publication:  United States
  • Année de publication électronique: 2004
  • Mois : Novembre
  • Pages: 345
  • DDC: 616
  • Langue: Anglais

An estimated forty million people carry the human immunodeficiency virus (HIV), and five million more become newly infected annually. In recent years, many HIV-infected patients in wealthy nations have enjoyed significantly longer, good-quality lives as a result of antiretroviral therapy (ART). However, most infected individuals live in the poorest regions of the world, where ART is virtually nonexistent. The consequent death toll in these regions—especially sub-Saharan Africa—is begetting economic and social collapse.

To inform the multiple efforts underway to deploy antiretroviral drugs in resource-poor settings, the Institute of Medicine committee was asked to conduct an independent review and assessment of rapid scale-up ART programs. It was also asked to identify the components of effective implementation programs.

At the heart of the committee's report lie five imperatives:

  • Immediately introduce and scale up ART programs in resource-poor settings.
  • Devise strategies to ensure high levels of patient adherence to complicated treatment regimens.
  • Rapidly address human-resource shortages to avoid the failure of program implementation.
  • Continuously monitor and evaluate the programs to form the most effective guidelines and treatment regimens for each population.
  • Prepare to sustain ART for decades.
  • Cover
  • Front Matter
  • Executive Summary
  • 1 Introduction
  • 2 Opportunities and Challenges
  • 3 Lessons Learned
  • 4 Principles of Scale-Up
  • 5 Managing Scale-Up of Antiretroviral Therapy
  • 6 The Path Forward
  • Appendix A: Information Gathering Workshop Agenda
  • Appendix B: Primer on Humanimmunodeficiency Virus, Acquired Immune Deficiency Syndrome and Antiretroviral Therapy
  • Appendix C: Scaling Up Antiretroviral Therapy in Resource-Limited Settings: Treatment Guidelines for a Public Health Approach
  • Appendix D: Human Ethical Issues Arising in ARV Scale-Up in Resource Constrained Settings
  • Appendix E: Human Resource Requirements for Scaling Up Antiretroviral Therapy in Low-Resource Countries
  • Appendix F: Glossary and Acronyms
  • Appendix G: Committee and Staff Biographies

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