The Origins of Schizophrenia synthesizes key findings on a devastating mental disorder that has been increasingly studied over the past decade. Advances in epidemiology, translational neuroscience technology, and molecular and statistical genetics have recast schizophrenia's neurobiological nature, identifying new putative environmental risk factors and candidate susceptibility genes. Providing the latest clinical and neuroscience research developments in a comprehensive volume, this collection by world-renowned investigators answers a pressing need for balanced, thorough information, while pointing to future directions in research and interdisciplinary collaboration.
The book, featuring a foreword by Robert Freedman, M.D., thoroughly examines these topics from the vantage points of epidemiologic, clinical, and basic neuroscience approaches, making it an essential resource for researchers in psychiatry, psychology, and neuroscience and for clinical mental health professionals.
- Contents
- Foreword
- Acknowledgments
- Introduction
- Overview
- Part 1. Clinical Research on Risk Factors for Schizophrenia
- Section 1: Environmental Factors: Epidemiologic Studies on the Etiologies of Schizophrenia
- 1 Maternal Infection and Schizophrenia
- 2 Prenatal Nutrition and the Etiology of Schizophrenia
- 3 Obstetric Complications and Schizophrenia: Historical Overview and New Directions
- 4 Maternal Stress During Pregnancy and Schizophrenia
- 5 Advancing Paternal Age and the Risk for Schizophrenia
- 6 Cannabis Use as a Component Cause of Schizophrenia
- Section 2: Genetics and Epigenetics
- 7 Schizophrenia Genetics: What Have We Learned from Genomewide Association Studies?
- 7 Genetic Architecture of Schizophrenia: The Contribution of Copy Number Variation
- 9 The Epigenetics of Schizophrenia
- Part 2. Preclinical Research on Etiologies of Schizophrenia
- Section 1: Animal Models of Environmental Factors and Schizophrenia
- 10 Animal Models of the Maternal Infection Risk Factor for Schizophrenia
- 11 Developmental Vitamin D Deficiency as a Risk Factor for Schizophrenia
- 12 Animal Models of Prenatal Protein Malnutrition Relevant for Schizophrenia
- 13 Animal Models of the Maternal Stress Risk Factor for Schizophrenia
- Section 2: Animal Models of Genetic Factors and Schizophrenia
- 14 Disc1: A New Paradigm for Schizophrenia and Biological Psychiatry
- 15 Mutant Models of Nrg1 and ErB4: Abnormalities of Brain Structures, Functions, and Behaviors Relevant to Schizophrenia
- Contributors
- Index
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