The past 20 years have seen a rapid increase in our understanding of the biology of cancer. And, advances in understanding the genetics of cancer are beginning to have an impact on the clinical management of malignant disease. Many of the genetic changes that underlie malignant transformation of cells and/or that distinguish malignant clones can be used as markers to diagnose, monitor, or characterize various forms of cancer.
The purpose of this volume is to assess the current status of genetic testing in cancer management both from the standpoint of those tests and genetic markers that are presently available and from the perspective of genetic approaches to cancer testing that are likely to have an impact on cancer management in the near future.
- ADVANCES IN UNDERSTANDING GENETIC CHANGES IN CANCER
- Copyright
- Statement of Purpose
- Contents
- ADVANCES IN UNDERSTANDING GENETIC CHANGES IN CANCER
- 1 Introduction
- OUTLINE OF MOLECULAR GENETICS
- BRIEF OVERVIEW OF CANCER GENETICS
- 2 Testing for Tumor-Specific Genetic Markers
- MICROSCOPIC DETECTION OF ALTERATIONS IN DNA STRUCTURE
- In Situ Hybridization
- Ploidy Analysis
- TECHNIQUES FOR DETECTING CHANGES IN DNA STRUCTURE AT THE SUBMICROSCOPIC LEVEL
- Southern Blot Hybridization
- Pulsed-Field Gel Electrophoresis
- Polymerase Chain Reaction
- TECHNIQUES FOR DETECTION OF POINT MUTATIONS IN DNA
- TECHNIQUES DIRECTED AT ANALYSIS OF RNA
- TECHNIQUES FOR ANALYZING CHANGES AT THE PROTEIN LEVEL
- 3 Hematologic Cancer
- CHRONIC MYELOGENOUS LEUKEMIA
- CHRONIC LYMPHOCYTIC LEUKEMIA
- ACUTE LYMPHOCYTIC LEUKEMIA
- ACUTE MYELOGENOUS LEUKEMIA
- MYELODYSPLASTIC SYNDROMES
- LYMPHOMA
- 4 Solid Tumors
- CHROMOSOMAL ABERRATIONS OF DIAGNOSTIC IMPORTANCE
- CHROMOSOMAL ABERRATIONS OF PROGNOSTIC IMPORTANCE
- Neuroblastoma
- Breast Cancer
- Lung Cancer
- Other Solid Tumors
- GENETIC MARKERS OF PREDISPOSITION TO CANCER
- Retinoblastoma
- Mapping of Other Cancer Predisposition Loci
- Li-Fraumeni Syndrome
- Loss of Heterozygosity in Sporadic Solid Tumors
- GENETIC CHANGES AND TUMOR PROGRESSION
- Colorectal Neoplasms
- Glial Tumors
- CANCER-ASSOCIATED GENETIC CHANGES AND ENVIRONMENTAL MUTAGENS
- VIRAL MARKERS IN CANCER DIAGNOSIS
- 5 Summary and Specific Recommendations
- PRACTICAL ASPECTS OF GENETIC ANALYSIS: FROM PATIENT TO DIAGNOSTIC LABORATORY
- THE MOLECULAR DIAGNOSTIC LABORATORY
- IMPLICATIONS OF COMMERCIALIZATION
- FUTURE NEEDS
- 6 References
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