The Development of Science-based Guidelines for Laboratory Animal Care is the summary of an international workshop held in Washington, DC, in November 2003 to bring together experts from around the world to discuss the available knowledge that can positively influence current and pending guidelines for laboratory animal care, identify gaps in that knowledge in order to encourage future research endeavors, and discuss the scientific evidence that can be used to assess the benefits and costs of various regulatory approaches affecting facilities, research, and animal welfare.
- FrontMatter
- Preface
- Contents
- Introduction
- Building the Case for Science-based Guidelines—Introductory Remarks--Hilton J. Klein
- Plenary Lecture
- Genes, Environments, and Mouse Behavior--John C. Crabbe
- Session 1 Current Status: Identifying the Issues
- AAALAC International Perspective--John G. Miller
- The Council of Europe: What Is It?--Wim deLeeuw
- ICLAS and the International Community--Gilles Demers
- Role of the National Institutes of Health Office of Laboratory Animal Welfare and the Public Health Service Policy on Humane Care and Use of Laboratory Animals--Nelson L. Garnett
- Regulatory Authority of the US Department of Agriculture Animal and Plant Health Inspection Service--Chester A. Gipson
- A Review and Comparison of Processes to Change Regulatory Guidelines: A European Perspective--Jonathan Richmond
- Japanese Regulations on Animal Experiments: Current Status and Perspectives--Naoko Kagiyama and Tatsuji Nomura
- Process for Change—Development and Implementation of Standards for Animal Care and Use in Canada--Clément Gauthier
- Building Credible Science from Quality, Animal-based Information--Paul Gilman
- Session 2 Assessment of Animal Housing Needs in the Research Setting— Peer-reviewed Literature Approach
- Disruption of Laboratory Experiments Due to Leaching of Bisphenol A from Polycarbonate Cages and Bottles and Uncontrolled Variability in Components of Animal Feed--Frederick S. vom Saal, Catherine A. Richter, Rachel R. Ruhlen, Susan C. Nagel, and Wade V. We
- Assessment of Animal Housing Needs in the Research Setting Using a Peer-reviewed Literature Approach: Dogs and Cats--Graham Moore
- Housing for Captive Nonhuman Primates: The Balancing Act--Melinda Novak
- Assessment of Animal Housing Standards for Rabbits in a Research Setting--Markus Stauffacher and Vera Baumans
- Session 3 Approaches to Current Guidelines— United States and Europe
- Housing Standards: Development of Guidelines and the Process for Change--William J. White
- Revision of Appendix A to the European Convention ETS 123: The Participants, the Process, and the Outcome--Derek Forbes
- Breakout Session: Rats and Mice
- Effects of Housing Density and Cage Type on Young Adult C57BL/6J Mice
- New Housing Standards for Rats and Mice Developed with Focus on the Needs of the Animals
- Breakout Session: Approaches for Implementing Current US and European Guidelines for Housing Standards for Dogs and Cats
- Breakout Session: Nonhuman Primates
- Breakout Session: Rabbit Housing
- Session 4 Environmental Control for Animal Housing
- Environmental Controls (US Guidance)--Bernard Blazewicz and Dan Frasier
- European Guidelines for Environmental Control in Laboratory Animal Facilities--Harry J. M. Blom
- Breakout Session: Lighting
- Breakout Session: Effects of Sound on Research Animals
- Breakout Session: Environmental Control for Animal Housing— Impact on Metabolism and Immunology
- Breakout Session: Environmental Control/ Engineering Issues
- Dinner Speaker--Kay E. Holekamp
- A View from the Field: What the Lives of Wild Animals Can Teach Us About Care of Laboratory Animals--Kay E. Holekamp
- Session 5 Environmental Enrichment Issues
- Enriching the Housing of the Laboratory Rodent: How Might It Affect Research Outcomes?--William T. Greenough and Ann Benefiel
- Search for Optimal Enrichment--Timo Nevalainen
- Breakout Session: Environmental Enrichment Issues: Mice/Rats/Rabbits
- Breakout Session: Environmental Enrichment for Dogs and Cats
- Breakout Session: Assessment of Nonhuman Primate Enrichment— Science Versus Welfare Concerns
- Point/Counterpoint: The Cases For and Against Harmonization
- Point/Counterpoint: The Cases For and Against Harmonization--William S. Stokes
- Appendixes
- Appendix A: International Workshop on Development of Science-based Guidelines for Laboratory Animal Care
- Appendix B: Workshop Faculty
- Appendix C: Committee Bios
- Appendix D: International Guiding Principles for Biomedical Research Involving Animals (1985)
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