At the request of the National Institute of Standards and Technology (NIST), the National Academies of Sciences, Engineering, and Medicine has, since 1959, annually assembled panels of experts from academia, industry, medicine, and other scientific and engineering environments to assess the quality and effectiveness of the NIST measurements and standards laboratories, as well as the adequacy of the laboratories' resources. This report assesses the scientific and technical work performed by the NIST Physical Measurement Laboratory in the Quantum Measurement Division, Radiation Physics Division, Sensor Science Division, Microsystems and Nanotechnology Division, and Nanoscale Device Characterization Division.