At the request of the National Institute of Standards and Technology (NIST), the National Academies of Sciences, Engineering, and Medicine has, since 1959, annually assembled panels of experts from academia, industry, medicine, and other scientific and engineering environments to assess the quality and effectiveness of the NIST measurements and standards laboratories. This report assesses the scientific and technical work performed by the NIST Information Technology Laboratory for the following divisions: Information Access, Software and Systems, and Statistical Engineering.